Calaspargase pegol
Asparlas (calaspargase pegol) is an enzyme pharmaceutical. Calaspargase pegol was first approved as Asparlas on 2018-12-20. It is used to treat precursor cell lymphoblastic leukemia-lymphoma in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Asparlas
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| asparlas | Biologic Licensing Application | 2023-12-06 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
calaspargase pegol, Asparlas, Servier Pharmaceuticals LLC | |||
| 2101-02-01 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
No data
HCPCS
Code | Description |
|---|---|
| J9118 | Injection, calaspargase pegol-mknl, 10 units |
Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 6 | 12 | 7 | — | 1 | 23 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 4 | 12 | 7 | — | 1 | 21 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | 12 | 6 | — | — | 18 |
| Lymphoma | D008223 | — | C85.9 | 2 | 8 | 2 | — | — | 11 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | — | 3 | 2 | — | — | 5 |
| Acute disease | D000208 | — | — | 1 | 2 | 1 | — | — | 4 |
| Philadelphia chromosome | D010677 | — | — | — | — | 2 | — | — | 2 |
| Central nervous system neoplasms | D016543 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 5 | — | — | — | 6 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 3 | 1 | — | — | — | 4 |
| Recurrence | D012008 | — | — | 1 | 2 | — | — | — | 3 |
| T-cell lymphoma | D016399 | — | — | 1 | 1 | — | — | — | 2 |
| T-cell lymphoma peripheral | D016411 | — | — | 1 | 1 | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| T-cell leukemia | D015458 | — | — | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Calaspargase pegol |
| INN | calaspargase pegol |
| Description | Calaspargase pegol, sold under the brand name Asparlas, is a medication for the treatment of acute lymphoblastic leukemia (ALL). It is approved in the United States as a component of a multi-agent chemotherapeutic regimen for ALL in pediatric and young adult patients aged one month to 21 years.
|
| Classification | Enzyme |
| Drug class | enzymes; PEGylated compounds, covalent attachment of macrogol (polyethylene glycol) polymer |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 941577-06-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108728 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB14730 |
| UNII ID | T9FVH03HMZ (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 90 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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347 adverse events reported
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